I have found it very useful... so I've thought I post it here.
https://kc.mcafee.com/corporate/index?page=content&id=KB68562&cat=CORP_SECURITY_FOR_MAC&actp=LIST
Corporate KnowledgeBase
Excluding folders with VirusScan for Mac with regular expressions
Corporate KnowledgeBase ID: KB68562
Version: 1.0
Status: Published
Created: March 19, 2010
Last Modified: April 28, 2010
Environment
Mac OS 10.6 (Snow Leopard)
Mac OS 10.5 (Leopard)
Mac OS 10.4.6 (Tiger)
Summary
This article describes how regular expressions (regex) can be utilized in order exclude folders from being scanned with VirusScan for Mac 9.x.
Solution
To exclude specific folders under the Users profile using regular expressions in McAfee VirusScan 9.x (also known as McAfee Security for Mac 1.0) from ePO (ePolicy Orchestrator):
/Users/.*/<your folder path>/.*
To exclude VMDK (Virtual Machine Disk) files residing anywhere on the Mac:
..vmdk - locally
/..vmdk - from ePO
To exclude any file based on extension:
..ext - locally
/..ext - from ePO
To exclude .log files from scanning:
..log - locally
/..log - from ePO
To excluding multiple files based on extensions
..(EXT)(EXT) - Locally
/..(EXT)(EXT) - From ePO
NOTE: the forward slash character (/) preceding the ePO commands is required when these policies are pushed from ePO due to a sanity check carried out by ePO.