EDIT: Removing the usual rant, worked with a Wacom dev team contact, verified these settings work with Monterey on Intel and M1:
Codesign commands, to gather the info needed for the PPPC configuration profile:
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/Wacom\\ Desktop\\ Center.app
Executable=/Applications/Wacom Tablet.localized/Wacom Desktop Center.app/Contents/MacOS/Wacom Desktop Center
designated => anchor apple generic and identifier "com.wacom.Wacom-Desktop-Center" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/Wacom\\ Display\\ Settings.app/
Executable=/Applications/Wacom Tablet.localized/Wacom Display Settings.app/Contents/MacOS/Wacom Display Settings
designated => anchor apple generic and identifier "com.wacom.Wacom-Display-Settings" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/Wacom\\ Tablet\\ Utility.app
Executable=/Applications/Wacom Tablet.localized/Wacom Tablet Utility.app/Contents/MacOS/Wacom Tablet Utility
designated => anchor apple generic and identifier "com.wacom.RemoveWacomTablet" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Library/PrivilegedHelperTools/com.wacom.IOManager.app
Executable=/Library/PrivilegedHelperTools/com.wacom.IOManager.app/Contents/MacOS/com.wacom.IOManager
designated => anchor apple generic and identifier "com.wacom.IOManager" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Library/PrivilegedHelperTools/com.wacom.DataStoreMgr.app
Executable=/Library/PrivilegedHelperTools/com.wacom.DataStoreMgr.app/Contents/MacOS/com.wacom.DataStoreMgr
designated => anchor apple generic and identifier "com.wacom.DataStoreMgr" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Library/PrivilegedHelperTools/com.wacom.UpdateHelper.app/
Executable=/Library/PrivilegedHelperTools/com.wacom.UpdateHelper.app/Contents/MacOS/com.wacom.UpdateHelper
designated => anchor apple generic and identifier "com.wacom.UpdateHelper" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/.Tablet/WacomTabletDriver.app
Executable=/Applications/Wacom Tablet.localized/.Tablet/WacomTabletDriver.app/Contents/MacOS/WacomTabletDriver
designated => anchor apple generic and identifier "com.wacom.wacomtablet" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/.Tablet/WacomTouchDriver.app
Executable=/Applications/Wacom Tablet.localized/.Tablet/WacomTouchDriver.app/Contents/MacOS/WacomTouchDriver
designated => anchor apple generic and identifier "com.wacom.WacomTouchDriver" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/.Tablet/TabletDriver.app
Executable=/Applications/Wacom Tablet.localized/.Tablet/TabletDriver.app/Contents/MacOS/TabletDriver
designated => anchor apple generic and identifier "com.wacom.TabletDriver" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
$ codesign -dr - /Applications/Wacom\\ Tablet.localized/.Tablet/FirmwareUpdater.app
Executable=/Applications/Wacom Tablet.localized/.Tablet/FirmwareUpdater.app/Contents/MacOS/FirmwareUpdater
designated => anchor apple generic and identifier "com.wacom.FirmwareUpdater" and (certificate leaf[field.1.2.840.113635.100.6.1.9] /* exists */ or certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = EG27766DY7)
Here are screenshots, using the above, to add the 10 items to a PPPC configuration profile:
com.wacom.IOManager:

com.wacom.UpdateHelper:

com.wacom.DataStoreMgr:

com.wacom.wacomtablet:

com.wacom.FirmwareUpdate:

com.wacom.WacomTouchDriver:

com.wacom.TabletDriver:

com.wacom.RemoveWacomTablet:

com.wacom.Wacom-Display-Settings:

com.wacom.Wacom-Desktop-Center:

Here are the items the user will now need to enable, since Apple won't let us do it for them:       



Nothing shows up under Accessibility, but that might be because we don't have a USB-C compatible Wacom tablet. If anyone has screenshots of the expected items, please punt them this way so I can update (with attribution!).

The above should end this annoying prompt:



