I was able to solve the After Effects approval by using the Privacy Preferences Policy Control Unit App to build out the PPPC.
In the Apple Events section, click the add button and select Finder.
Bonus: If you are deploying Wacom drivers, you need to allow the tablet in Illustrator. To do that, select Apple Events, add button, Other. navigate to /Library/Application Support/Tablet/WacomTabletDriver.app.

Years ago I stopped trying to ‘fix’ the changes Apple makes to the UX. Educating the users is going to be easier in most cases (scroll wheel direction, dock location, etc). Yeah, there are still things that we try and manage, but less and less each OS release. 😕

@mscheffler where you able to figure out how to allow the NWEA Testing Browser?

@dsweigart Our tech guy at the high school was able to get it working, but we're not fully compliant with all of NWEA's wishful thinking on things they want disabled.

@SCADtom Love the "bonus" tip.

I am experiencing challenges with this and the following apps:
Zoom
VirtualBox
PPPC is new to me and I don't even know where to start.

I can confirm @SCADtom Method working on 10.15.X.

May I add the following:

Make sure you build the PPPC Profile with the same Adobe Package(s) you are creating/uploading from the Adobe Admin Console.

Manually Creating PPPC Configuration Profiles:
As noted by @bernard.Huang codesign -dr - /path/to/app will help with creating PPPC Profiles manually on Jamf if not using the PPPC Utility to automate the tasks.

Kext Configuration Profiles:
Keep in mind that Kext(Kernel extensions) are different than PPPC configuration profile. To verify kernel extensions, run this to look at the KextPolicy database on your system:

sqlite3 /var/db/SystemPolicyConfiguration/KextPolicy

To view approved KEXTs in the sqlite3 database:

SELECT * FROM kext_policy;

This should show what KEXTs have been approved on your Mac. You can proceed to enter Team Bundle/ID on Jamf.

I recommend creating a profile for each application and I know this sounds like a lot of work but this will make it easier for future management and explicit for when troubleshooting or making changes.. Make sure to append the version of the Adobe package after just in case you are running different versions or have to service multiple versions in the future for scoping. I have attached a few examples.

Hope this helps anyone having issues.

I tried that command in Terminal @MikeyJAP and this is what I got, any ideas? This is on my VM as well as my Macbook.

Try SELECT * from kext_policy_mdm;.

Thanks @donmontalvo , the kext_policy_mdm; will work with BigSur.