What are you trying to disable specifically? Not everything can be disabled with configuration profile by Apple design. Some things that cannot be disabled can be hidden with a plist. It all depends on what exactly you are trying to manage.

Hi essentially just some system preferences, but school boy error i rebooted the mac and the restrictions worked, never had to do that before, i was used to send the profile you see the screen refresh and get the result but it seems you need to reboot 12.4 we live and learn

thanks

Oh, lol. Ya, when you drop new restrictions macOS needs to "update". You can also run sudo JAMF manage which should apply any new configurations that are "pending a reboot" to apply.